Ripoptosome: a novel lAP-regulated cell death-signalling platform

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2011,（6）
• 页码范围: 324-326
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/jmcb/mjr034

摘要

Recent studies have revealed that cell death stimuli can trigger programmed necrosis,necroptosis.Receptor-interacting serinethreonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and necroptosis.Two studies now describe a novel RIP1 containing ～2 MDa 'Ripoptosome' complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 stimulation.Intriguingly,clAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.