L-Serine Decreases Taurine Concentration in the Extracellular Fluid of Brain Slices

• 作者: Donald Michael Denbow Kazutaka Shigemi Kohsuke Hayamizu Koji Tanaka Mitsuhiro Furuse
• 来源期刊: 神经系统科学与医药(英文)
• 学科: 医学
• 关键词: L-SERINE CHICK Brain SLICE TAURINE L-ALANINE
• 年，卷（期）: 2011,（3）
• 页码范围: 268-274
• 页数: 7页
• 分类号: R73

摘要

L-Serine is considered a functional amino acid in the central nervous system, and induces sedation and hypnotic effects in some animal models of acute and chronic stress. Accordingly, while L-serine is a candidate anti-stress factor, the central mechanism of L-serine is not clear. The present study clarifies the action of L-serine using acute chick brain slices. We investigated the changes in some extracellular fluid amino acid concentrations in response to L-serine perfusion. Taurine concentration decreased while L-alanine concentration increased following L-serine perfusion. To examine the involvement of the taurine transporter, the effect of L-serine on the taurine concentration in the presence and absence of Na+ was also investigated. Na+ had no effect on taurine concentration induced by L-serine perfusion. These results suggest that L-serine has an ability to promote L-alanine synthesis facilitating the catabolism of taurine. In conclusion, L-serine modifies the metabolism of taurine and L-alanine in the extracellular space in chick brain.