Applications of post-translational modifications of FoxO family proteins in biological functions

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2011,（5）
• 页码范围: 276-282
• 页数: 7页
• 语种: 中文
• DOI: 10.1093/jmcb/mjr013

摘要

The functions of the FoxO family proteins,in particular their transcriptional activities,are modulated by post-translational modifications (PTMs),including phosphorylation,acetylation,ubiquitination,methylation and glycosylation.These PTMs occur in response to different cellular stresses,which in turn regulate the subceilular localization of FoxO family proteins,as well as their half-life,DNA binding,transcriptional activity and ability to interact with other cellular proteins.In this review,we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.