Fractional stochastic description of hinge motions in single protein molecules

• 来源期刊: 科学通报(英文版)
• 学科: 生物学
• 关键词: 分子运动 分数 蛋白质 分子动力学模拟 动力学模型 铰链 随机 核糖核酸酶
• 年，卷（期）: 2011,（6）
• 页码范围: 496-502
• 页数: 7页
• 分类号: Q51
• 语种: 中文

摘要

In this study, it is demonstrated that the motion of hinges in single protein molecules can be modeled as general fractional Langevin dynamics of harmonically bound particles driven by non-local Gaussian noise with a power-law correlation. This conclusion was justified by comparing the theoretical predictions of the proposed model to the existing molecular dynamics simulations performed on the M6I mutant of phage T4 lysozyme and E. coli ribonuclease H1.