OxLDL induced p53-dependent apoptosis by activating p38MAPK and PKCδ signaling pathways in J774A.1 macrophage cells

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2011,（5）
• 页码范围: 316-318
• 页数: 3页
• 语种: 中文
• DOI: 10.1093/jmcb/mjr019

摘要

Dear Editor,The sub-endothelial retention of lipoproteins is one of the key events that trigger the atherosclerosis process.Low-density lipoprotein (LDL) particles trapped within the arterial wall are prone to progressive oxidation by monocytes/macrophages.Oxidized LDL (oxLDL) is present in atherosclerotic lesions,and has been suggested to play a significant role in atherogenesis (Nishi et al.,2002).The pathophysiology of atherosclerosis involves both apoptosis and proliferation at different stages of the vessel lesion.In advanced atherosclerotic plaques,up to 50％ of the apoptotic cells are macrophages,which may promote core expansion and plaque instability (Tabas et al.,2009).