Structural basis for mechanochemical role of Arabidopsis thaliana dynamin-related protein in membrane fission

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2011,（6）
• 页码范围: 378-381
• 页数: 4页
• 语种: 英文
• DOI: 10.1093/jmcb/mjr032

摘要

Dear Editor Dynamins and dynamin-related proteins (DRPs) constitute a large superfamily of GTPases throughout animal,plant,and bacteria and play essential roles in core cellular processes (Praefcke and McMahon,2004).Plant specific dynamin-related subfamilies share essential functions with those in mammalian cell,e.g.clarthrinmediated endocytosis and fission of mitochondria;yet they also play unique functional roles in plant cells (Hong et al.,2003;Chen et al.,2011;Xue et al.,2011)(Supplementary Figure S1).Key features of dynamin members,including large molecular size,high basal GTP hydrolysis,and self-assembly into filamentous helices,distinguish them from other classical signaling and regulatory GTPases (Praefcke and McMahon,2004).