Highlights on FOX03 and tumor-associated dendritic cells in prostate cancer

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2011,（5）
• 页码范围: 657-658
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2011.78

摘要

Cancer immunotherapy sometimes fails to provoke effective immune responses because of immunosuppressive mechanisms present in the tumor-bearing host.Dendritic cells (DCs) are the most potent antigenpresenting cells.After internalizing tumorassociated antigens (TAAs) at the tumor site,CCR7+ DCs traffic to the tumor-draining lymph nodes,where they influence the maturation of T cells.DCs may also be present at the tumor site.These tumor-associated DCs (TADCs) cross-present TAAs to recruited CD8+ T cells,which develop into TAA-specific effector cells.When activated,TADCs can mediate the sensitization of naive T cells that have been recruited into the tumor site.For this reason,interaction between tumor-infiltrating T cells and TADCs is essential for activating and maintaining specific antitumor immune responses.