Green spermatozoa illuminate a 30-year-old model:sperm-egg adhesion involves intra-acrosomal proteins

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2011,（5）
• 页码范围: 665-666
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2011.95

摘要

Fertilisation in mammals involves many synchronized steps including spermegg adhesion.Prior to sperm-oolemma fusion,spermatozoa need to undergo the acrosome reaction (AR) or exocytosis.The universal belief,for many years,has been that the AR was initiated upon binding to the zona pellucida (ZP).As such acrosomal proteins were not thought to be involved in the primary contact with the ZP.These proteins were only suggested to be biologically relevant once the sperm were attached to the ZP and during subsequent events.However,recent data in the mouse have unequivocally demonstrated that spermatozoa can begin exocytosis before contact with ZP.1 It is a remarkable finding as not only will the interpretation of the interaction between sperm and cumulus cells need to be revised,but the processes of capacitation,vesiculation and exposure of acrosomal content need reexamination.