Vasoactive Intestinal Peptide (VIP) and VIP Receptors-Elucidation of Structure and Function for Therapeutic Applications

• 作者: Hisato Igarashi Kazuhiko Nakamura Koichi Suzuki Nao Fujimori Robert T Jensen Ryoichi Takayanagi Taichi Nakamura Takamasa Oono Tetsuhide Ito
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: Vasoactive INTESTINAL PEPTIDE VIP VPAC
• 年，卷（期）: 2011,（4）
• 页码范围: 500-508
• 页数: 9页
• 分类号: R73

摘要

Vasoactive intestinal peptide (VIP) is a 28-amino acid polypeptide first isolated from swine duodenum. VIP is a neurotransmitter that is extensively distributed in tissues. According to published reports, VPAC1 and VPAC2 act as VIP receptors and are widely present in the central nervous system and peripheral tissues. VIP exerts diverse actions on the cardiovascular system, pancreas, digestive tract, respiratory system, and urological system. Recent reports indicated that VIP has immunological and neuroprotective effects and also affects cell growth. While primary investigations for developing therapeutic applications for various pathological conditions and diseases are underway, the structure and function of VIP should be analyzed in more detail.