FADD: an endogenous inhibitor of RIP3-driven regulated necrosis

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（10）
• 页码范围: 1383-1385
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2011,147

摘要

Thanks to the work of multiple laboratories worldwide,the classical dichotomy postulating that apoptosis and necrosis would constitute diametrically opposed cell death subroutines has recently been dismissed [1].Thus,approximately in the same year when immunogenic instances of apoptosis were first characterized [2],the traditional belief that necrosis would represent a merely accidental,unregulated cell death modality has been definitely abandoned [3].This has fueled an intense wave of research,advancing our understanding of the molecular mechanisms and pathophysiological implications of regulated necrosis [4,5].