Mark the transition: chromatin modifications and cell fate decision

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（10）
• 页码范围: 1388-1390
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2011.154

摘要

With their unique features of selfrenewal and pluripotency,human embryonic stem (hES) cells are considered to be a nearly unlimited resource for research and clinical applications [1].Accordingly,the transcriptional network specifying and governing human ES cell identity has been extensively studied.OCT4,NANOG and SOX2 form a core transcriptional network that regulates itself as well as a number of target genes [2].This transcriptional network acts together with signaling pathways to maintain ES cell identity [3].Moreover,the last decade has seen tremendous advances in understanding the epigenetic mechanisms underlying ES eell self-renewal and pluripotency.