New blood brothers: the GPR55 and CB2 partnership

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（10）
• 页码范围: 1391-1392
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2011.77

摘要

Endocannabinoids are increasingly being recognized as key lipid-derived regulators of immune function [1].Although the peripheral cannabinoid type 2 receptor (CB2) is thought to orchestrate many of these actions,additional non-CB1/CB2-mediated effects ofcannabinoids have been identified in immune cells [1,2],where several orphan G protein-coupled receptors (GPCRs),including the effusive GPR55,are implicated [3].Despite numerous studies addressing the cannabinoid sensitivity of GPR55,the area remains a pharmacological minefield,with much inconsistent and conflicting data.