Purging and isolating pluripotent cells, "sweet" dreams become true?

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（11）
• 页码范围: 1526-1527
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2011.163

摘要

The formation of an adult organism could be viewed as a hierarchical process in which the initial totipotent cell,the zygote,progressively loses "potency" by differentiating into pluripotent,multipotent and unipotent states until the final terminally differentiated cells comprising tissues and organs are derived.Such a unidirectional concept trembled when four transcription factors were shown to "revert" the identity of differentiated somatic cells and reprogram them into induced pluripotent stem cells (iPSCs) [1].