Putting muscle in DNA methylation

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（11）
• 页码范围: 1531-1533
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2011.91

摘要

Over 25 years ago seminal experiments from the labs of Peter Jones and Harold Weintraub demonstrated that alteration in the DNA modification state underlie the myogenic conversion of fibroblast cell lines [1,2].This paved the way for the identification of myogenic helix-loop-helix (HLH) proteins in muscle differentiation,but the mechanism by which DNA methylation regulates muscle differentiation has remained elusive [3].