Spermatids do it differently! Paip2a-the essential regulator of spermiogenesis?

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2011,（1）
• 页码范围: 122-124
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/aja.2010.142

摘要

The mechanisms underpinning the latter stages of spermiogenesis are poorly understood and male germ cells have been presumed to extensively employ post-transcriptional regulatory machinery,in order to produce the highly differentiated spermatozoa,in the absence of newly synthesized gene transcripts.Excitingly,in a recently published paper in the Journal of Clinical Investigation,1two groups at McGill University,using null mouse models,have identified a crucial role of the poly(A)-binding protein-interacting protein 2(Paip2a),in translational activation and protein homeostasis in the transcription-ally quiescent and terminally differentiating elongating spermatids.