Mitochondrial ROS fuel the inflammasome

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（4）
• 页码范围: 558-560
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2011.20

摘要

ILβ-1and IL-18 are pro-inflammatory cytokines that play a critical role in the response to a diverse array of injuries and infections.Accordingly, the production of these potent cytokines is tightly regulated at transcriptional and post-translational levels through control of both maturation and secretion.The maturation of these cytokines is regulated by caspase-1 inflammasomes.Several members of the Nod-like receptor (NLR) family of intracellular sensors,including NLRP3, NLRC4 and NLRP1,play critical roles in inflammasome regulation.However, the nature of the physiological cues that trigger inflammasome activation remain incompletely understood.