Essential role of DOT1L in maintaining normal adult hematopoiesis

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（9）
• 页码范围: 1370-1373
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2011.115

摘要

Dear Editor,Histone methylation plays important roles in regulating gene expression and diverse biological processes [ 1 ].Methylation of a unique residue,lysine 79 of histone H3 (H3K79),is evolutionarily conserved from yeast to human and is catalyzed by yeast Dotl (disruptor of telomeric silencing) and its mammalian homolog DOT1L (Dotl-Like),respectively [2].