Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（9）
• 页码范围: 1374-1378
• 页数: 5页
• 语种: 英文
• DOI: 10.1038/cr.2011.124

摘要

Dear Editor,UHRF1 (ubiquitin-like,containing plant homeodomain (PHD) and RING finger domains,1),also known as ICBP90 in human and NP95 in mouse,is a critical regulator of maintenance of CpG DNA methylation through targeting de novo DNA methyltransferase (DNMT1) to hemimethylated replication forks;its ablation leads to genomic hypomethylation and cell cycle arrest [1,2].