Effective gene silencing in Drosophila ovarian germline by artificial microRNAs

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（4）
• 页码范围: 700-703
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2011.44

摘要

Dear Editor, Drosophila oogenesis is of great interest because it represents an excellent model system to study a number of fascinating biological processes, such as stem cell regulation, germ cell meiosis and oocyte determination, as well as signal interactions between germline and soma.A typical Drosophila ovary is composed of 16-20 ovarioles, each consisting of an anterior functional unit called a germarium and a linear string of differentiated egg chambers posterior to the germarium [1] (Figure 1A and 1B).Drosophila oogenesis initiates at the tip of the germarium, when a germline stem cell (GSC) divides asymmetrically to generate a daughter GSC and a cystoblast that eventually develops into a mature egg [2] (Figure 1C and 1E).