Redox Factor-1 Mediates Inflammatory Response during Tumor Promotion in Skin Epidermal JB6 Cells

• 作者: Delira Robbins Katie Humphrey Wenjuan Li Yunfeng Zhao
• 来源期刊: 细胞凋亡(英文)
• 学科: 医学
• 关键词: REF-1 TUMORIGENESIS JB6 CELLS Tumor PROMOTION CHEMOPREVENTION
• 年，卷（期）: 2012,（3）
• 页码范围: 19-24
• 页数: 6页
• 分类号: R73

摘要

Recently, redox factor-1 (Ref-1) has received considerable attention as an enzyme for stimulating tumor cell growth. We hypothesized that Ref-1 is upregulated during the early stage of tumorigenesis. Utilizing both tumor promotion sensitive P+ and promotion resistant P? mouse skin epidermal JB6 cells, we found that Ref-1 expression was only induced in tumor promotion sensitive P+ cells following TPA treatment. Consistent with that, Ref-1 knockdown suppressed skin cell transformation. Interestingly, Ref-1 knockdown suppressed nuclear translocation of NF-kappaB subunit p65, and inhibited production of proinflammatory cytokines. These results suggest Ref-1 may promote early tumorigenesis and serve as a target for chemoprevention.