Oxidative stress-mediated effects of angiotensinⅡin the cardiovascular system

• 作者: Hairuo Wen Judith K Gwathmey Lai-Hua Xie
• 来源期刊: 世界高血压杂志
• 学科: 医学
• 关键词: AngiotensinⅡ Oxidative stress MITOCHONDRIA ARRHYTHMIAS ISCHEMIA-REPERFUSION HYPERTROPHY Hypertension
• 年，卷（期）: 2012,（4）
• 页码范围: 34-44
• 页数: 11页
• 分类号: R972

摘要

AngiotensinⅡ(AngⅡ),an endogenous peptide hormone,plays critical roles in the pathophysiological modulation of cardiovascular functions.AngⅡis the principle effector of the renin-angiotensin system for maintaining homeostasis in the cardiovascular system,as well as a potent stimulator of NAD(P)H oxidase,which is the major source and primary trigger for reactive oxygen species(ROS)generation in various tissues.Recent accumulating evidence has demonstrated the importance of oxidative stress in AngⅡ-induced heart diseases.Here,we review the recent progress in the study on oxidative stress-mediated effects of AngⅡin the cardiovascular system.In particular,the involvement of AngⅡ-induced ROS generation in arrhythmias,cell death/heart failure,ischemia/reperfusion injury,cardiac hypertrophy and hypertension are discussed.Ca2+/calmodulin-dependent protein kinaseⅡis an important molecule linking AngⅡ,ROS and cardiovascular pathological conditions.