Anticardiolipin antibodies do not mediate macrovascular complications of type 2 diabetes

• 作者: Caroline Eickhoff Copetti Henrique Luiz Staub Melissa Claudia Bisi Myriam Perreynoud
• 来源期刊: 内科学期刊(英文)
• 学科: 医学
• 关键词: ANTICARDIOLIPIN ANTIBODIES Type 2 Diabetes MELLITUS Myocardial INFARCTION CEREBROVASCULAR INFARCTION
• 年，卷（期）: 2012,（1）
• 页码范围: 37-39
• 页数: 3页
• 分类号: R5

摘要

The relationship of anticardiolipin antibodies (ACA), markers of the antiphospholipid syndrome, with vascular complications of diabetes mellitus is polemic. This cross-sectional study assessed the frequency of IgG, IgM, and IgA ACA in type 2 diabetics with and without history of vascular events for the last 5 years, and in healthy controls. ACA were detected by enzyme immunoassay. A total of 73 type 2 diabetics (33 with history of vascular events) and 54 healthy controls were tested. Most diabetics were female (p = 0.003), and older than controls (p 0.09). ACA positivity rates were also similar when diabetics with and without history of vasculopathy were compared (p > 0.47). After adjusting for gender, age, hypertension, and smoking status, a weak but statistically insignificant association between IgM ACA and diabetics with vasculopathy was found (adjusted OR 2.7;95% CI 0.2 - 34.2;p = 0.441). Overall, levels of IgG (r = 0.25;p = 0.005) and IgM (r = 0.23;p = 0.010) ACA were associated with increasing age. In short, the frequency of a positive ACA test in type 2 diabetics (with or without previous macrovasculopathy) was not significant as compared to healthy controls. There was no association of ACA with vascular events in patients with type 2 diabetes.