Combining active immunotherapy with immune checkpoint blockade for the treatment of advanced prostate cancer

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2012,（4）
• 页码范围: 520-521
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2012.45

摘要

Combination immunotherapy is emerging as a promising approach for the treatment of advanced prostate cancer.This research highlight discusses the combination of a PSA-directed poxviral vaccine and a monodonal antibody blocking an important immune checkpoint molecule to treat men with metastatic castrationresistant prostate cancer.The results demonstrate feasibility and safety,as well as intriguing clinical responses to this combination therapy.