Single-Chain Fragmented Antibodies Guided SiRNA Delivery in Breast Cancer

• 来源期刊: 中国科学基金（英文版）
• 年，卷（期）: 2012,（1）
• 页码范围: 24
• 页数: 1页
• 语种: 英文

摘要

Over the past ten years,the enthusiasm to harness small RNA molecules,mainly small interfering RNAs (siRNAs) and microRNA mimics,into therapeutic weapons has never been quenched.However,a major obstacle hindering the clinical application of these small molecules is how to efficiently and precisely deliver siRNAs in vivo into target cells to silence target genes.An international collaborative study led by Song Erwei from the Memorial Hospital of Sun-Yat-Sen University and Wang Jun from Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences of University of Science and Technology of China has now shed light on the possibility of targeting anti-cancer siRNAs directly to the tumor cells using single-chain fragmented antibodies (ScFvs).