Pumilio 1 control of spermatogenesis: a roadmap for future research

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2012,（5）
• 页码范围: 669
• 页数: 1页
• 语种: 英文
• DOI: 10.1038/aja.2012.38

摘要

In this novel paper,1 the authors examined the role of a ubiquitously expressed testicular protein,Pumilio I,which is a posttranscriptional regulator of spermatogenesis in the testis.The mechanism of action of this regulatory protein is based on its binding to the 3' end of mRNAs that code for kinases that regulate the p53 protein (most prominently eight of these mRNAs),which causes a Pumilio 1 binding-mcdiatcd activation of p53,and the consequent suppression of apoptosis in spermatocytes.In Pumilio 1-mutant mice,apoptosis occurs primarily in spermatocytes,which interrupts sequential male gamete development and thus reduces the fertility of the affected mice.Additional support for this mechanism came from experiments in which p53 was inhibited in mice which subsequently showed a reduction in spermatocyte apoptosis.The data also provided further evidence regarding the mRNA regulation proposed by Keene2 which states that the multifunctional mRNAs are not physically linked,but that each mRNA cistron carries a common sequence motif that is recognized by a shared regulator,as exemplified by Pumilio 1,and its repression of the eight p53 activators.