Leucyl-tRNA synthetase: double duty in amino acid sensing

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（8）
• 页码范围: 1207-1209
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.68

摘要

The cellular response to amino acids is controlled at the molecular level by TORC1.While many of the elements that participate in TORC1 signaling are known,we still have no clear idea how cells sense amino acids.Two recent studies found that leucyltRNA synthetase (LRS) is a leucine sensor for TORC1,in both yeast and mammalian cells.