Will the real aging Sirtuin please stand up?

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（8）
• 页码范围: 1215-1217
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.62

摘要

Initial studies linking Sirtuins to longevity in yeast initiated what is now a rich vein of aging research that is full of promise and fraught with controversy.Missing was a demonstration that enhanced Sirtuin expression extends lifespan in mammals.Now Kanfi et al.provide the evidence but with an interesting plot twist - the lesser known SIRT6 is the longevity factor.