CUL4B ubiquitin ligase in mouse development: A model for human X-linked mental retardation syndrome?

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（8）
• 页码范围: 1224-1226
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.79

摘要

CUL4B,a member of the cullinRING ubiquitin ligase family,is frequently mutated in X-linked mental retardation (XLMR) patients.The study by Liu et al.showed that Cul4b plays an essential developmental role in the extra-embryonic tissues,while it is dispensable in the embryo proper during mouse embryogenesis.Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.