Implications of the prostate intervention versus observation trial (PIVOT)

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2012,（6）
• 页码范围: 815
• 页数: 1页
• 语种: 英文
• DOI: 10.1038/aja.2012.103

摘要

Prostate intervention versus observation trial (PIVOT) is the largest and longest randomized trial conducted in men with early stage prostate cancer detected during the era of wide-spread prostate-specific antigen (PSA) testing.1 PIVOT enrolled 731 men and followed them for up to 15 years after randomization.PIVOT results demonstrate that compared to observation,radical prostatectomy did not result in a significant reduction in all cause or prostate cancer mortality through at least 12 years among men with localized prostate cancer;absolute differences were less than 3％.Results changed little after 8 years;therefore,additional follow-up is unlikely to change our findings.Radical prostatectomy caused related harms within 30 days of surgery in 21％ of men and urinary incontinence and erectile dysfunction through at least 2 years.