Establishing a cancer cell in the inflammatory tissue: an epigenetic circuit

• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2012,（4）
• 页码范围: 279-280
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/abbs/gms021

摘要

Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide.Risk factors,such as viral infection,aflatoxin intake,and alcohol abuse,induce frequent hepatic cell death and chronic liver pathologies.It has now been well accepted that dead hepatocytes trigger a local inflammatory response,including increased inflammatory cytokines secretion and immune cell infiltration.Repeated cell death and compensatory proliferation in a background of chronic inflammation is believed to lead to the transformation of surviving cells that may carry genetic mutations;therefore,ultimately enhancing tumor initiation and promotion [1].