Ventricular Tachycardia during Treatment with Modafinil for Narcolepsy: A Case Report

• 作者: Gerard C. M. Linssen Hanno L. Tan Heleen Binnenmars Herman H. D. Idzerda
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: MODAFINIL NARCOLEPSY VENTRICULAR TACHYCARDIA
• 年，卷（期）: 2012,（6）
• 页码范围: 513-517
• 页数: 5页
• 分类号: R5

摘要

Pharmacological treatment of narcolepsy is complex. We reported a case of recurrent episodes of polymorphic ventricular tachycardia attributed to the use of modafinil, a recently approved wake-promoting agent for narcolepsy and shift work sleep disorder. Modafinil is also approved as adjunctive treatment of obstructive sleep apnea/hypopnea syndrome. While the exact mechanism of action for modafinil is not known, central dopamine receptors seem to play an essential role. Adverse influences on the electrocardiogram (ECG) or drug-related cardiac arrhythmias are rarely reported, but are considered as clinically important.