Continuous Renal Replacement Therapy Clearance Rate for Salicylate Toxicity in Multi-System Trauma

• 作者: Daniel Silverman L. Keith French Robert G. Hendrickson
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: CRRT CLEARANCE Rate SALICYLATE Toxicity Multisystem TRAUMA
• 年，卷（期）: 2012,（6）
• 页码范围: 552-553
• 页数: 2页
• 分类号: R6

摘要

The management of patients with concomitant xenobiotic toxicity and multisystem trauma can be complex. While hemodialysis is generally the modality of choice for extracorporeal elimination of salicylates, the potential for large volume shifts and hypotension may pose a risk in patients with traumatic brain injury. An alternative therapy to hemodialysis is continuous renal replacement therapy, which has slower clearance rates than hemodialysis, but has decreased adverse effects in cases of traumatic brain injury. However, there are few published reports of clearance rates of salicylates using continuous renal replacement therapy. We report a case of multisystem trauma with concomitant intentional salicylate overdose in which continuous renal replacement therapy was employed. The salicylate clearance rate that was obtained in this case was 7.5 mL/minute using continuous veno-venous hemodiafiltration, a form of continuous renal replacement therapy.