Autophagy is required for self-renewal and differentiation of adult human stem cells

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（2）
• 页码范围: 432-435
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2011.200

摘要

Dear Editor,Patients receiving anticancer therapy usually suffer from side effects,such as loss of hair,epithelial barrier defects,and myelosuppression,which,however,are usually reversible when the therapy is discontinued.Although this clinical experience suggests that adult stem cells may survive such therapeutic interventions,the underlying molecular regulatory mechanisms are poorly understood.Such regulatory mechanisms also seem to protect adult stem cells from acquiring mutations,which could lead to additional tumorigenesis.