New approach to paricalcitol synthesis

• 来源期刊: 科学通报(英文版)
• 学科: 工学
• 年，卷（期）: 2012,（14）
• 页码范围: 1616-1619
• 页数: 4页
• 分类号: TQ466.4
• 语种: 中文

摘要

Paricalcitol,an analog of vitamin D,is used as a drug for the prevention and treatment of secondary hyperparathyroidism.In this paper,a new strategy for the synthesis of paricalcitol is described.This approach includes three main improvements:one-pot regioselective ozonization cleavage of the side-chain and methylene at C-19,free-radical reduction removal of the OH group formed at C-19,and side-chain assembly using a Wittig reaction.These are all new strategies for the synthesis of 19-nor-vitamin D2 compounds.