Versatility of the translational machinery during stress:changing partners to keep dancing

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（12）
• 页码范围: 1634-1636
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.102

摘要

Cap-dependent translation is initiated by the binding of eIF4E to the cap structure at the 5′ end of mRNAs.During hypoxic stress,global translation decreases because eIF4E is inactivated.In a recent article in Nature,Lee and colleagues show that residual hypoxic translation is maintained by a specialized isoform of eIF4E,which binds to target mRNAs in complex with a hypoxia-induced RNP.