Mechanisms of Prostate Atrophy after LHRH Antagonist Cetrorelix Injection: An Experimental Study in a Rat Model of Benign Prostatic Hyperplasia

• 来源期刊: 华中科技大学学报(医学)(英德文版)
• 学科: 医学
• 年，卷（期）: 2012,（3）
• 页码范围: 389-395
• 页数: 7页
• 分类号: R697.3
• 语种: 中文

摘要

In the present study, we investigated the roles of TGF-β signaling pathway in a rat benign prostatic hyperplasia (BPH) model treated with cetrorelix. TGF-β1 and c-Myc expression were measured by qRT-PCR and Western blotting in the proximal and distal region of ventral prostatic lobes, respectively. We observed that treatment with cetrorelix led to a significant reduction of ventral prostate weight in a dose-dependent manner. In the proximal region, after cetrorelix treatment, the expression of TGF-β1 was dramatically increased (P<0.05), while the expression of c-Myc was significantly decreased (P<0.05). In comparison with the control group, the cetrorelix groups had more TUNEL-positive cells. Our findings strongly suggest that the TGF-β signaling pathway may be one of the major causes responsible for prostate volume reduction in BPH rats after cetrorelix treatment.