Pull and push: Talin activation for integrin signaling

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（11）
• 页码范围: 1512-1514
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.103

摘要

The inside-out signaling of integrins regulates the ligand-binding affinity of the cell surface receptors in response to changes in the environment for cell survival.The specific binding to the cytoplasmic tail of integrin's β subunit by the intracellular protein talin is the key step of insideout signaling.A "pull-push" mechanism has been proposed to explain how the PIP2-enriched membrane disrupts the dual auto-inhibition of the N-terminal talin-FERM domain by the C-terminal talin-rod domain such that activated talin-FERM can reach the β-tail for integrin activation.