A new paradigm in viral resistance

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（11）
• 页码范围: 1515-1517
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.139

摘要

The rapid mutation of RNA viruses allows for the acquisition of resistance to drugs directly targeting viral proteins.Therefore,a novel approach to the development of antivirals centers on targeting host factors critical to viral replication.A recent report has brought to light the potential for RNA viruses to also develop resistance against compounds targeting crucial host factors,suggesting that a combination of drugs with various targets may be necessary for preventing resistance.