Telomere length and iPSC re-programming: survival of the longest

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（4）
• 页码范围: 614-615
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2012.6

摘要

A hallmark feature of pluripotent stem cells is the ability to proliferate indefinitely (immortal phenotype).Despite reactivation of telomerase during iPSC derivation,there exists considerable heterogeneity in telomere length amongst established iPSC cell lines.Both telomerase-dependent and -independent mechanisms have now been shown to be important for continuous self-renewal of iPSC via the maintenance or extension of telomere length. The pluripotent stem cells that constitute the inner cell mass of the early blastocyst must have the capacity to go through many rounds of cell division to allow completion of embryonic development.Not surprisingly,these embryonic stem cells exhibit long telomeres and the enzymatic complex telomerase,which functions to complete telomere replication,is present at relatively high levels [1,2].