Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（5）
• 页码范围: 928-931
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2012.27

摘要

Dear Editor, The incidence of lung cancer from never smokers has increased dramatically in China nowadays.Strikingly,approximately 30％ of the lung cancer patients in East Asian population are never smokers [1,2].The majority of these patients are females with lung adenocarcinomas [2].Identification of oncogenic drivers,which the tumors are "addicted to" and rely on for survival,has significantly reformed the current strategies for lung cancer treatment in clinic and initiated the era of personalized therapy [3].Therapeutics specifically targeting EGFR mutations,frequently observed in never smoker patients with lung cancer,have been very helpful in improving the clinical symptoms as well as the progression-free survival [4-6].Similarly,patients with lung tumors positive for ALK fusions also benefit from ALK-targeted therapy [7,8].