Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（6）
• 页码范围: 1078-1081
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2012.72

摘要

Dear Editor, Dosage compensation of the male X-chromosomal genes in Drosophila results from acetylation of histone H4 Lysl6 (H4KI6) along the male X-chromosome by the MSL (male-specific lethal) complex [1].The MSL complex comprises five proteins (MSLI,MSL2,MSL3,MLE and MOF),as well as two non-coding RNAs (roX1 and roX2).The enzymatic activity of histone acetyltransferase (HAT) MOF (males-absent on the first) is tightly regulated by MSL1 and MSL3 [2-4].MSLI tethers MOF with the regulatory factor,the MRG domain of MSL3,through two adjacent regions at its C-terminus [4,5].Only in complex with MSL1 and MSL3,MOF is capable of specifically acetylating nucleosomal H4K16 [4,5].