Molecular basis of the acetyltransferase activity of MEC-17 towards α-tubulin

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（12）
• 页码范围: 1707-1711
• 页数: 5页
• 语种: 英文
• DOI: 10.1038/cr.2012.154

摘要

Dear Editor,Adaptation of microtubules to the structural and functional complexities involves diverse post-translational modifications of tubulins,including acetylation,tyrosination,detyrosination,polyglycylation,polyglutamylation,palmitoylation,and phosphorylation.In particular,acetylation of α-tubulin affects the cell motility and plays an important role in neuronal migration and differentiation [1].Specifically,acetylation of Lys40 of α-tubulin has prominent impacts on polarized protein trafficking and hence protein transport by promoting the binding of dynein/dynactin and kinesin-1 motor complexes[2,3].