Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（4）
• 页码范围: 773-776
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/cr.2012.17

摘要

Dear Editor,The in vitro propagation (IVP) of animal spermatogonial stem cells (SSCs) provides materials for studying the mechanism of spermatogenesis and for developing novel animal transgenesis and human therapy.The IVP of SSCs is reported to be promoted by exogenous growth factors,among which the glial cell-derived neurotrophic factor (GDNF) has been recognized as the single essential one [1,2].FGF2,a prototypical member of the FGF family,has been reported to be required for the IVP of SSCs from some mouse strains [2].The single-copy FGF2 gene generates one low-molecular weight (LMW)and several high-molecular weight (HMW) protein isoforms as a result of alternative translation initiations.