Bax promoter G(-248)A polymorphism in a Turkish clinical breast cancer patients: A case-control study

• 作者: Ender Coskunpinar Ilhan Yaylim Nazli Ezgi Ozkan Saime Turan Seden Kucucuk Soykan Arikan Turgay Isbir Yemliha Yildiz
• 来源期刊: 美国分子生物学期刊(英文)
• 学科: 医学
• 关键词: Bcl-2 Associated-X-Protein SNP Apoptosis PCR SUSCEPTIBILITY CARCINOGENESIS
• 年，卷（期）: 2013,（1）
• 页码范围: 10-16
• 页数: 7页
• 分类号: R73

摘要

Bax is an important protein involved in apoptotic process. Mutations of the Bax gene are known to af- fect protein expression and function. A promotor polymorphism G(-248)A in the 5’UTR of Bax gene may alter regulation of apoptosis in carcinogenesis. Our study was performed to test the association be- tween G(-248)A polymorphisms in the Bax gene and breast cancer risk and progression. G(-248)A poly- morphism was genotyped in a Turkish breast cancer, case-control population including 53 female cancer patients (mean age ± SD: 60.9 ± 11.9 years) and 82 controls (mean age ± SD: 57.2 ± 17.5 years) using PCR-RFLP analysis. Genotype and allele frequencies were assessed with the chi-square test. There was no difference in the distribution of Bax genotypes, and allele frequencies were G (87.7% versus 88.4%) and A (12.3% versus 11.6%) in the cancer patients and controls, respectively. Within the cancer group, the presence of a polymorphic Bax G(-248)A allele was not associated with clinico-pathological parameters such as advanced tumor stage, lymph node or distant metastasis. We present the first to report on Bax G(-248)A polymorphisms in breast cancer. Our re- sults suggest that Bax G(-248)A polymorphism do not modify individual susceptibility to invasive breast cancer in Turkish women.