Constipation is one of the most common complaints in the general population, with a wide variety of causes. We present the case of a man with a four-week history of constipation who developed signs and symptoms of acute cholecystitis. Computed tomography scan of the abdomen revealed emphysematous cholecystitis and pericholecystic inflammatory changes extending to the adjacent colon. Emergent cholecystectomy was performed, and bowel function improved after surgery. Chronic inflammation of the gallbladder might be associated with constipation in this patient.