ISG15 regulates IFN-γ immunity in human mycobacterial disease

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2013,（2）
• 页码范围: 173-175
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.133

摘要

Interferon-gamma (IFN-γ) is crucial for immunity against different pathogens due to its broad effects on the multiple arms of the immune system.The regulation of IFN-γ immunity is of extensive interest to research as well as practical activity for drug discovery.New evidence supports previous findings that ubiquitin-like protein ISG15 acts as an extracellular cytokine and promotes IFN-γ production,providing intriguing insights of the importance of ISG15into the control of human mycobacterial disease.