在 utero 移植：迥异的分枝

• 作者: John S Pixley Esmail D Zanjani
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: Self NON-SELF DISCRIMINATION IMMUNE ONTOGENY Stem cell transplantation
• 年，卷（期）: 2013,（2）
• 页码范围: 43-52
• 页数: 10页
• 分类号: R459.9

摘要

In utero stem cell transplantation,which promises treatment for a host of genetic disorders early in gestationbefore disease effect stems from Ray Owen’s seminalobservation that self-tolerance,is acquired duringgestation.To date,in utero transplantation(IUT)hasproved useful in characterizing the hematopoietic stemcell.Recent observations support its use as an in vivomethod to further understanding of self-tolerance.Preclinical development continues for its application asa treatment for childhood hematolymphoid diseases.In addition,IUT may offer therapeutic options in thetreatment of diabetes among other diseases.ThusIUT serves as a technique or system important in botha basic and applied format.This review summarizesthese findings.