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摘要:
Amniotic fluid stem cells(AFSC) are noncontroversial and abundant potentially transplantable cells. They are derived from fetal and amniotic sources and show osteogenic, neuronal, and adipogenic differentiation in culture. Clinical material must be expanded in culture and sorted if clinical use is desired. Cellular senescence and replicative potential for AFSC cultures has had limited study, with scant data on gene expression over time. We report changes in samples from 17 patients over multiple passages form 10 to 81 population doublings. Longevity was unrelated to telomere length in these cells. It was related to upregulation of TWIST1, which is highly expressed in stem cells, and downregulation of genes associated with apoptosis.
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篇名 Senescence and longevity in amniotic fluid derived cells
来源期刊 干细胞探索(英文) 学科 医学
关键词 Amniotic FLUID Stem Cells SENESCENCE LONGEVITY TELOMERES GENES
年,卷(期) 2013,(1) 所属期刊栏目
研究方向 页码范围 47-55
页数 9页 分类号 R73
字数 语种
DOI
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Amniotic
FLUID
Stem
Cells
SENESCENCE
LONGEVITY
TELOMERES
GENES
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
干细胞探索(英文)
季刊
2161-6760
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
83
总下载数(次)
0
总被引数(次)
0
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