The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Expression of NF-κb and MCP-1 in Rats with Silicosis

• 作者: Fang Yang Hong Xu Lijuan Zhang Qian Li Wenli Zhang
• 来源期刊: 清洁煤炭能国际期刊(英文)
• 学科: 医学
• 关键词: N-acetyl-seryl-aspartyl-lysyl-proline SILICOSIS MONOCYTE Chemotactic Protein-1 NUCLEAR Factor-κb
• 年，卷（期）: 2013,（2）
• 页码范围: 24-26
• 页数: 3页
• 分类号: R73

摘要

In the present study, we developed silicosis of rat model by bronchial perfusion SiO2 dust, and intervenes with AcSDKP, immunohisto chemistry was used to detect NF-κb and MCP-1 expression in lung tissue, and positive cells were counted. We found that compared with silicotic model group, the positive cells of NF-κb and MCP-1 were decreased significantly in anti-fibrosis treatment of AcSDKP group. The findings suggest that AcSDKP could inhibit the expression of NF-κb and MCP-1 in lung tissue of silicosos, this may be related to AcSDKP inhibit of macrophage infiltration in lung tissue and reduced the degree of dust alveolitis.