Hot topics in lupus pregnancy

• 作者: Javier A Cavallasca Cecilia A Costa Maria del Rosario Maliandi Jorge L Musuruana
• 来源期刊: 世界风湿病学杂志
• 学科: 医学
• 关键词: Systemic LUPUS ERYTHEMATOSUS PREGNANCY PRE-ECLAMPSIA LUPUS NEPHRITIS NEONATAL LUPUS ERYTHEMATOSUS Congenital heart block
• 年，卷（期）: 2013,（3）
• 页码范围: 32-39
• 页数: 8页
• 分类号: R

摘要

Systemic lupus erythematosus(SLE)typically affects women in their childbearing age,who have the same fertility rates as the healthy population.The effect of pregnancy on the disease and the effect of SLE on pregnancy and the fetus are highly important issues for the attending physician.Whether lupus flares are more frequent during pregnancy remains controversial.Among the possible effects of SLE on pregnancy are a greater number of abortions,fetal loss,pre-term deliveries and perinatal mortality.The newborn may be affected by the onset of neonatal lupus erythematosus(neonatal LE),either as a skin or blood disease,or by the presence of congenital heart block.The frequent association between SLE and antiphospholipid syndrome represents another risk situation for the mother and the product of conception.Multiples drugs used in SLE patients should be evaluated.Those with teratogenic potential should be withdrawn before pregnancy,and when necessary,appropriate medications should be indicated to treat the mother without compromising the safety of the baby.In conclusion,pregnancies in lupus patients represent a challenge for the physician and must be closely followed up and treated if necessary,during all trimesters and in the puerperium period,to improve outcome.